Abstract: 
Orally disintegrating/ rapid dissolving tablets are an emerging trend in novel drug ‎delivery system. This can be attained by addition of different excipients, from ‎which disintegrant is the key adjuvant. In the present work, an attempt has been ‎made to develop rapid disintegrating tablets of Ciprofloxacin by fabricating an ‎extra-superdisintegrant and incorporates as a tablet buster. A solvent evaporation ‎method of co processing was used to form a composite extra-super disintegrant ‎from sodium starch glycolate and croscarmellose sodium. Blend of all the ‎formulations showed good flow properties such as angle of repose, bulk density, ‎tapped density. All the formulations were prepared by direct compression ‎method using 8mm punch on single station Carver hydraulic press and evaluated ‎for tablet properties. The co-processed extra-superdisintegrants were also ‎characterized by FTIR Studies. There was no chemical interaction between drug ‎and excipients. The in-vitro disintegration times (DT) of rapid dissolving tablets ‎were found to be 3.03±0.06 to 20.0±2.0seconds. The composite extra ‎superdisintegrant “CSD5” produced RDT “CTCSD5” with crushing strength of 9.40 ‎‎+ 0.62, DT of 3.40 + 0.06 seconds, this could be a promising approach to enhance ‎tablet breakdown, with subsequent increase in drug dissolution and improved ‎bioavailability. The novel extra-superdisintegrant showed significant reduction in ‎DT when compared with the primary composite (P<0.05). The designed and ‎engineering of the novel extra-super disintegrant was excellent, and the ‎utilization in the formulation of rapid disintegrating tablet was a success.‎

Keywords: Extra Superdisintegrant, ‎ Rapid Disintegrating Tablets, ‎Mouth Disintegrating, Fast Disintegrating Tablets, ‎Ciprofloxacin Fast Dissolving ‎Tablets.‎