Abstract:  
The preferred technique to increase the solubility of several medicines has been solid dispersion. Using the appropriate medium or polymer in conjunction with the solid dispersion of one or more active pharmaceutical ingredients in a carrier at a solid state is necessary to improve the dissolution of some low water-soluble medications and thus increase their bioavailability. It has attracted a lot of attention as a way to quicken up the disintegration rate. It occurs as a result of dispersing some water-soluble carriers with some weakly water-soluble medications to improve the pharmaceuticals’ disintegration. The solubility performance of pharmaceuticals is one of the most challenging areas of dosage form formulation and development. The amount of weakly water-soluble chemicals has significantly grown, prompting extra care to make them more soluble. The manufacture of solid dispersions must take into account a few factors, such as the choice of carrier and physicochemical characterization techniques. A brief overview of solid dispersion, including its characteristics, benefits, drawbacks, and uses in different formulations, is provided in this review article.

Keywords:  Solubility, Dissolution, Solid Dispersion, Carrier, Bioavailability.