Development and characterization of a composite “extra superdisintegrant” from sodium starch glycolate and croscarmellose sodium and its evaluation in rapid disintegrating ciprofloxacin tablets
Abiodun O Shittu, Ibn U Umar, Ngaitad S Njinga
Abstract:
Orally disintegrating/ rapid dissolving tablets are an emerging trend in novel drug delivery system. This can be attained by addition of different excipients, from which disintegrant is the key adjuvant. In the present work, an attempt has been made to develop rapid disintegrating tablets of Ciprofloxacin by fabricating an extra-superdisintegrant and incorporates as a tablet buster. A solvent evaporation method of co processing was used to form a composite extra-super disintegrant from sodium starch glycolate and croscarmellose sodium. Blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. All the formulations were prepared by direct compression method using 8mm punch on single station Carver hydraulic press and evaluated for tablet properties. The co-processed extra-superdisintegrants were also characterized by FTIR Studies. There was no chemical interaction between drug and excipients. The in-vitro disintegration times (DT) of rapid dissolving tablets were found to be 3.03±0.06 to 20.0±2.0seconds. The composite extra superdisintegrant “CSD5” produced RDT “CTCSD5” with crushing strength of 9.40 + 0.62, DT of 3.40 + 0.06 seconds, this could be a promising approach to enhance tablet breakdown, with subsequent increase in drug dissolution and improved bioavailability. The novel extra-superdisintegrant showed significant reduction in DT when compared with the primary composite (P<0.05). The designed and engineering of the novel extra-super disintegrant was excellent, and the utilization in the formulation of rapid disintegrating tablet was a success.
Keywords: Extra Superdisintegrant, Rapid Disintegrating Tablets, Mouth Disintegrating, Fast Disintegrating Tablets, Ciprofloxacin Fast Dissolving Tablets.